Tuesday, April 29, 2014

What are the frequent symptoms of a mast cell activation disorder or mastocytosis?

The frequent symptoms of a mast cell activation disorder or mastocytosis are generally of an inflammatory nature and multisystemic.  The various manifestation of inflammation are often unusual or atypical as well.

Dr. Theoharides categorizes the symptoms this way:

Orophayngeal: burning pain, aphthae

Dermatologic: flushing, pruritus, urticaria pigmentosa, angioedema, dermatographism (sometimes)

Respiratory: wheezing, sore throat

Cardiovascular: chest pain, hypotension, tachycardia

Gastrointestinal: abdominal pain, nausea, vomiting, diarrhea, bloating, malabsorption, esophagitis

Naso-ocular: nasal stuffiness, pruritus

Neurologic: headache, memory and concentration difficulties/brain fog, paresthesia, peripheral neuropathy

Muscoskeletal: bone/muscle pain, degenerative disc disease, osteoporosis/osteopenia

Systemic: anaphylaxis, fatigue

Abdominal: abdominal pain, intestinal cramping and bloating, diarrhea and/or obstipation, nausea, non-cardiac chest pain, Helicobacter pylori-negative gastritis, malabsorption
Respiratory: cough, asthma-like symptoms, dyspnea, rhinitis, sinusitis
Ophthalmologic: conjunctivitis, difficulty in focusing
Hepatic: splenomegaly, hyperbilirubinemia, elevation of liver transaminases, hypercholesterolemia
Cardiovascular: tachycardia, blood pressure irregularity (hypotension and/or hypertension(, syncope, hot flush
Neuropsychiatric: headache, neuropathic pain, polyneuropathy, decreased attention span, difficulty in concentration, forgetfulness, anxiety, sleeplessness, organic brain syndrome, vertigo, lightheadedness, tinnitus
Cutaneous: uticaria pigmentosa, hives, efflorescences with/without pruritus, telangiectasia, flushing, angiodema
Abnormal bleeding

Musculoskeletal: muscle pain, osteoporosis/osteopenia, bone pain, migratory arthritis

Interstitial cystitis
Constitutional: fatigue, asthenia, fever, environmental sensitivities

As you can see, numerous areas of the body are impacted.  If you have many of these symptoms covering several different systems you, too, might have a cell activation disorder or mastocytosis.